Dear Sender,

Biotin is fairly stable to air, heat, and light as well as acid, and at neutral pH. It is slightly unstable in alkali.  D-Biotin is very slightly soluble in water (approx. 0.02 g per 100 ml) and in ethanol, and practically insoluble in organic solvents. However, our experience indicates that the presence of alkali significantly improves the overall water solubility.

As it pertains to the application mentioned in the question, there used to be a method in the 1960s and 1970s of incorporating dry water-soluble forms and fat-soluble vitamins into an aqueous preparation. This required the use of an emulsifying agent to produce a homogeneous and physically stable formulation. However, methods for this application are no longer available, and to the best of our knowledge, this process is currently not in use in the industry today.

An alternative approach would involve adding the biotin (as is) directly into the oil blend using the right mixing and excipients to prevent settling.  The success of this approach would also depend on the level of biotin and the overall percentage of all solids (by weight) being added to the blend or final formulation.

In the end, whether you attempt to solubilize the biotin in water and combine with the oil-soluble product by preparing an emulsion, or incorporate the biotin (as is) directly into the oily blend, significant formulation and development are absolutely necessary to achieve the right blend for your final product.  This sounds like a very interesting product application!  DSM Nutritional Products has the product knowledge, formulation, and blending expertise to assist in such applications.  Please contact us directly to find out more about our products and services in this area.